Clinical Observations

PANS Evidence for Biological Validity

Download my ai summary of: Han, V.X., Alshammery, S., Keating, B.A., et al. (2025). Epigenetic, ribosomal, and immune dysregulation in paediatric acute-onset neuropsychiatric syndrome. Molecular Psychiatry. https://doi.org/10.1038/s41380-025-03127-5

Date Prepared: 6th September 2025, using Claude (Anthropic’s AI assistant)

PANS: School

Download my summary of information, additional sources of information, and some of my clinical observations relevant to planning for accommodations at school.

PDA in PANS Flares

Download my summary of resources for oppositional behaviours (PDA) in PANS.

PANS and Psychiatric Medicine - Research

Download my summary of four peer-reviewed research articles documenting PANS neuroimmune influences on response to psychiatric medication. Treatment Guidelines advice to START LOW, AND GO SLOW, due to a leaky blood brain barrier (BBB) causing atypical and paradoxical side effects, even at typically low doses.

PANS and immune investigations

Download my PANS summary with: Laboratory Workup recommendations and considerations from the PANDAS Physicians Network (PPN), ASPIRE, Stanford PANS Clinic research, and Ayla Wilson (Naturopath). Also a special mention for Dr Jenny Frankovich on youtube "Arthritis and neurological soft signs in Basal Ganglia inflammation".

If you suspect ongoing inflammation, LOOK FURTHER!